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Pecqueur L, Duellberg C, Dreier B, Jiang Q, Wang C, Plückthun A, Surrey T, Gigant B, Knossow M. (2012) A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A. 109(30):12011-6.

W. Wang, Q. Jiang, M. Argentini, D. Cornu, B. Gigant, M. Knossow, C. Wang (2012) Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J. Biol. Chem. 287, 15143-53.

Mignot I, Pecqueur L, Dorleans A, Karuppasamy M, Ravelli RB, Dreier B, Plueckthun A, Knossow M, Gigant B. (2012) Design and characterization of modular scaffolds for tubulin assembly. J. Biol. Chem. 287(37):31085-94

Ranaivoson FM, Gigant B, Berritt S, Joullié M, Knossow M. (2012) Structural plasticity of tubulin assembly probed by vinca-domain ligands. Acta Crystallogr D Biol Crystallogr. 68(Pt 8):927-34.

Nawrotek A, Knossow M, Gigant B.
The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J Mol Biol. 2011 Sep 9;412(1):35-42.

Fauquant C, Redeker V, Landrieu I, Wieruszeski JM, Verdegem D, Laprévote O, Lippens G, Gigant B, Knossow M.
Systematic Identification of Tubulin-interacting Fragments of the Microtubule-associated Protein Tau Leads to a Highly Efficient Promoter of Microtubule Assembly.
J Biol Chem. 2011 Sep 23;286(38):33358-68


Barbier P, Dorléans A, Devred F, Sanz L, Allegro D, Alfonso C, Knossow M, Peyrot V, Andreu JM.
Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers.
J Biol Chem. 2010 Oct 8;285(41):31672-81

Cormier A, Knossow M, Wang C, Gigant B.
The binding of vinca domain agents to tubulin: structural and biochemical studies.
Methods Cell Biol. 2010;95:373-90. Review.

Dorleans A, Gigant B, Ravelli RB, Mailliet P, Mikol V, Knossow M
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin.
Proc Natl Acad Sci USA 2009 106, 13775-13779.

Cormier A, Clement MJ, Knossow M, Lachkar S, Savarin P, Toma, F, Sobel A, Gigant B, Curmi, PA.
The PN2-3 domain of centrosomal P4.1-associated protein implements a novel mechanism for tubulin sequestration.
J Biol Chem 2009 284, 6909-6917.

Cormier A, Marchand M, Ravelli RB, Knossow M, Gigant B.
Structural insight into the inhibition of tubulin by vinca domain peptide ligands.
EMBO Rep. 2008 Sep 12. [Epub ahead of print]

Wang, C., Cormier, A., Gigant, B. and Knossow, M.
Insight into the GTPase activity of tubulin from complexes with stathmin-like domains.
Biochemistry 2007 46(37):10595-602


B. Gigant, C. Wang, R. B. G. Ravelli, F. Roussi, M.O. Steinmetz, P.A. Curmi, A. Sobel and M. Knossow
Structural Basis For The Regulation Of Tubulin By Vinblastine
Nature 2005 ; 435(7041):519-22

Ravelli, R. B., Gigant, B., Curmi, P. A., Jourdain, I., Lachkar, S., Sobel, A. & Knossow, M.
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
Nature 2004 ; 428: 198-202.


Gigant B, Curmi PA, Martin-Barbey, C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M.
The 4 Angström X-ray structure of a tubulin:stathmin-like domain complex
Cell 2000 ; 102:809-816.

Curmi PA, Andersen SS, Lachkar S, Gavet O, Karsenti E, Knossow M, Sobel A.
The stathmin/tubulin interaction in vitro.
J Biol Chem. 1997 ;272(40):25029-25036.


Eghiaian F., Grosclaude J., Lesceu S., Debey P., Doublet B., Tréguer E., Rezaei H. and Knossow M.
Insight into the PrPc-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.
P.N.A.S. 2004  101, 10254-9

Influenza virus neutralization

Knossow, M., and Skehel, J. J.
Variation and infectivity neutralization in influenza.
Immunology 2006 ; 119, 1-7.

Knossow, M., Gaudier, M., Douglas, A., Barrère B., Bizebard T., Barbey C., Gigant B. and Skehel J.J.
Mechanism of neutralization of influenza virus infectivity by antibodies.
Virology 2002 ; 302, 294-298.

Barbey-Martin, C., Gigant, B., Bizebard, T., Calder, L. J., Wharton, S. A., Skehel, J. J., and Knossow, M.
An Antibody that Prevents the Hemagglutinin Low pH Fusogenic Transition.
Virology 2002 ; 294, 70-74

Bizebard, T., Barbey-Martin, C., Fleury, D., Gigant, B., Barrère, B., Skehel, J.J. & Knossow, M.
Structural Studies on Viral Escape from Antibody Neutralization
Current Topics in Microbiology and Immunology 2001 ; Antibodies in Viral Infection, D. R. Burton Editor

Fleury D, Barrere B, Bizebard T, Daniels RS, Skehel JJ, Knossow M.
A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site.
Nat Struct Biol. 1999 ;6(6):530-534.

Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T.
Antigen distortion allows influenza virus to escape neutralization .
Nat Struct Biol. 1998 ;5(2):119-123.

Bizebard T, Gigant B, Rigolet P, Rasmussen B, Diat O, Bosecke P, Wharton SA, Skehel JJ, Knossow M.

Structure of influenza virus haemagglutinin complexed with a neutralizing antibody
Nature. 1995 ;376(6535):92-4.


Gaudier, Y. Gaudin and M. Knossow
Crystal structure of vesicular stomatitis virus matrix protein.
EMBO J. 2002 ; 21, 2886-2892.

Catalytic antibodies

L.J. D'Souza, B. Gigant, M. Knossow and B.S. Green.
Remarkable Remote Chiral Recognition in a Reaction Mediated by a Catalytic Antibody
J. Am. Chem. Soc. 2002 ; 124, 2114-2115.

Golinelli-Pimpaneau B, Gonçalves O, Dintinger T, Blanchard D, Knossow M, Tellier C.
Structural evidence for a programmed general base in the active site of a catalytic antibody .
Proc Natl Acad Sci U S A. 2000 ; 97(18):9892-9895.

Gigant B, Tsumuraya T, Fujii I, Knossow M.
Diverse structural solutions to catalysis in a family of antibodies.
Structure Fold Des. 1999 ;7(11):1385-1393.

Gigant B, Charbonnier J, Eshhar Z, Green BS, Knossow M.
Crossreactivity, efficiency and catalytic specificity of an esterase-like antibody .
J Mol Biol. 1998 ;284(3):741-750.

Gigant B, Charbonnier JB, Eshhar Z, Green BS, Knossow M.
X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Proc Natl Acad Sci U S A. 1997 ;94(15):7857-7861.

Charbonnier JB, Gigant B, Golinelli-Pimpaneau B, Knossow M.
Similarities of hydrolytic antibodies revealed by their X-ray structures .
Biochimie. 1997 ;79(11):653-660.

Gigant B, Charbonnier JB, Golinelli-Pimpaneau B, Zemel RR, Eshhar Z, Green BS, Knossow M.
Mechanism of inactivation of a catalytic antibody by p-nitrophenyl esters.
Eur J Biochem. 1997 ;246(2):471-476.

Charbonnier JB, Golinelli-Pimpaneau B, Gigant B, Tawfik DS, Chap R, Schindler DG, Kim SH, Green BS, Eshhar Z, Knossow M.
Structural convergence in the active sites of a family of catalytic antibodies .
Science. 1997 Feb 21;275(5303):1140-1402.

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